The ALDOB Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to ALDB, Aldo2, and Aldob. This antibody recognizes Human, Mouse, and Rat antigen. The ALDOB Antibody has been validated for the following applications: Western Blot.
Description
Fructose-1,6-bisphosphate aldolase (EC 4.1.2.13) is a tetrameric glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Vertebrates have 3 aldolase isozymes which are distinguished by their electrophoretic and catalytic properties. Differences indicate that aldolases A, B, and C are distinct proteins, the products of a family of related 'housekeeping' genes exhibiting developmentally regulated expression of the different isozymes. The developing embryo produces aldolase A, which is produced in even greater amounts in adult muscle where it can be as much as 5% of total cellular protein. In adult liver, kidney and intestine, aldolase A expression is repressed and aldolase B is produced. In brain and other nervous tissue, aldolase A and C are expressed about equally. There is a high degree of homology between aldolase A and C. Defects in ALDOB cause hereditary fructose intolerance.Paolella G., Nucleic Acids Res. 12:7401-7410(1984).Sakakibara M., Nucleic Acids Res. 13:5055-5069(1985).Rottmann W.H., Proc. Natl. Acad. Sci. U.S.A. 81:2738-2742(1984)